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Rev. bras. med. esporte ; 29: e2022_0489, 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1423601

ABSTRACT

ABSTRACT Introduction: Basketball is a sport with high demands for physical and mental quality. Weakness in any aspect can easily cause damage to the body, with joints being the most stressed parts and extremely vulnerable to damage. Objective: Verify the effectiveness of the application of physical training in reducing physical injuries in basketball players. Methods: In this study, a total of 124 college students who participated in basketball at 4 universities were volunteers for the research, divided into a control group and an experimental group for an 8-week protocol. During the experiment, the control group participated in basketball four times a week for 6 hours without any intervention measures. Results: The experimental group participated in basketball four times a week for 6 hours, adding 4 times a week plus an additional 4 hours of physical training. It was found that the statistics of sports injuries in the experimental group were significantly lower than those in the control group (p<0.01), and the degree of sports injuries in the experimental group was slightly lower than that found in the control group. Conclusion: Eight weeks of 32-hour physical training can prevent sports injuries in college student basketball, providing physical protection for basketball players and preventing sports injuries. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução: O basquetebol é um esporte com altas exigências para a qualidade física e mental. A fraqueza em qualquer aspecto pode facilmente causar danos ao corpo, sendo as articulações as partes mais estressadas e extremamente vulneráveis a danos. Objetivo: Verificar a eficácia da aplicação do treinamento físico na redução de lesões físicas dos jogadores de basquetebol. Métodos: Neste trabalho, um total de 124 estudantes universitários que participam do basquete em 4 universidades foram voluntários para a pesquisa, divididos em grupo controle e grupo experimental para um protocolo de 8 semanas. Durante o experimento, o grupo de controle participou do basquetebol quatro vezes por semana durante 6 horas sem nenhuma medida de intervenção. Resultados: O grupo experimental participou do basquetebol 4 vezes por semana durante 6 horas, acrescentando 4 vezes por semana, mais 4 horas adicionais de treinamento físico. Verificou-se que as estatísticas de lesões esportivas no grupo experimental foram significativamente menores do que as do grupo controle (p<0,01), sendo o grau de lesões esportivas no grupo experimental ligeiramente menor do que a encontrada no grupo controle. Conclusão: Oito semanas de treinamento físico de 32 horas podem evitar lesões esportivas no basquetebol dos estudantes universitários, proporcionando proteção física aos jogadores de basquete e evitando a ocorrência de lesões esportivas. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción: El baloncesto es un deporte con altas exigencias de calidad física y mental. La debilidad en cualquier aspecto puede causar fácilmente daños en el cuerpo, siendo las articulaciones las partes más estresadas y extremadamente vulnerables a los daños. Objetivo: Verificar la eficacia de la aplicación del entrenamiento físico en la reducción de las lesiones físicas en los jugadores de baloncesto. Métodos: En este trabajo, un total de 124 estudiantes universitarios que participan en el baloncesto en 4 universidades fueron voluntarios para la investigación, divididos en un grupo de control y un grupo experimental para un protocolo de 8 semanas. Durante el experimento, el grupo de control participó en baloncesto cuatro veces a la semana durante 6 horas sin ninguna medida de intervención. Resultados: El grupo experimental participó en baloncesto cuatro veces por semana durante 6 horas, añadiendo 4 veces por semana más 4 horas adicionales de entrenamiento físico. Se comprobó que las estadísticas de lesiones deportivas en el grupo experimental eran significativamente inferiores a las del grupo de control (p<0,01), y el grado de lesiones deportivas en el grupo experimental era ligeramente inferior al encontrado en el grupo de control. Conclusión: Ocho semanas de entrenamiento físico de 32 horas pueden prevenir las lesiones deportivas en el baloncesto de los estudiantes universitarios, proporcionando protección física a los jugadores de baloncesto y previniendo la aparición de lesiones deportivas. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

2.
Journal of Southern Medical University ; (12): 257-263, 2019.
Article in Chinese | WPRIM | ID: wpr-772059

ABSTRACT

OBJECTIVE@#Citron Rho-interacting serine/threonine kinase (CIT) was identified recently as an oncogene involved in the progression of various malignant tumors, but its role in prostate cancer (PCa) remains unclear. In this study, we aimed to investigate the biological functions of CIT in PCa.@*METHODS@#We analyzed the expression of CIT in PCa tissues and its clinical correlations based on the Cancer Genome Atlas (TCGA) and Memorial Sloan-Kettering Cancer Center (MSKCC) dataset. We then examined the effects of RNA interference-mediated CIT silencing on the proliferation, migration and invasion of PC-3 cells using cell counting kit-8, wound healing assay and Transwell assay. We also investigated the effect of CIT silencing on epithelial-mesenchymal transition (EMT) and Hippo-Yap signaling pathway in the cells using Western blotting.@*RESULTS@#CIT expression was significantly elevated in PCa tissues from TCGA cohort ( < 0.05). MSKCC dataset analysis showed that an elevated expression of CIT was significantly correlated with N stage (=0.001), distant metastasis ( < 0.001), Gleason score (=0.010) and PSA (=0.004). In cultured PC-3 cells, knockdown of CIT significantly inhibited cell proliferation, migration and invasion, reversed the EMT phenotype and decreased the expression and activity of YAP.@*CONCLUSIONS@#CIT might function as an oncogene in PCa by modulating the Hippo-YAP signaling pathway and serve as a candidate therapeutic target for PCa.


Subject(s)
Humans , Male , Adaptor Proteins, Signal Transducing , Cell Line, Tumor , Cell Movement , Cell Proliferation , Neoplasm Metastasis , Phosphoproteins , Prostatic Neoplasms , Protein Serine-Threonine Kinases , Serine , Signal Transduction
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